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pentobarbital will minimize the level or impact of gefitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or influence of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is often a delicate CYP3A4 substrate. Coadministration with potent or average CY

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